Renal cell carcimoma (RCC) is the
third most common genitourinary cancer after
prostate and bladder. Majority (80% to 85%) of kidney tumours are malignant. It is the most lethal malignancy of all
urological cancers1
Unique
characteristics of RCC
- lack of early warning signs,
- diverse clinical manifestations,
- resistance to radiation and
chemotherapy, and
- immunogenic nature and
spontaneous regressions.
RCC diagnosed early can be
managed with nephron sparing or radical nephrectomy with excellent 5 year
survival and prognosis. The problematic cases are those presenting as advanced
disease at the initial presentation. The advanced
disease includes: T4 N0 M0, or any T, any N, M1. These cases are associated with poor survival
and limited treatment options. This review aims to through some light on our
current understanding of the pathogenic mechanisms, and the available treatment
options for the management of advanced RCC.
Pretreatment features associated with shorter
survival
There are various studies identifying
the pretreatment factors associated with poor survival. These are
–
Low
Karnofsky performance status (< 80%)
–
High
lactate dehydrogenase level (<; 1.5 x normal)
–
Low
hemoglobin level
–
High
serum calcium
–
Absence
of nephrectomy
·
Nephrectomy
and resection of metastases has been reported to prolong the survival. Effect is enhanced with long
disease-free interval between initial nephrectomy and development of metastases.
·
Survival
also depends on the site of metastasis. Patients with lung metastasis only have
better survival than those with other site metastasis.(Flanigan RC, et al. N Engl J Med. 2001; 345: 1655-1659.)
THALIDOMIDE:
Thalidomide is
reported to suppress levels of several cytokines, angiogenic growth factors including TNF-, basic fibroblast growth factor (bFGF), vascular
endothelial growth factor (VEGF) and interleukin-6 (IL-6). The resulting
anti-angiogenic, immunomodulatory and growth suppressive effects form the
rationale for investigating thalidomide in the treatment of malignancies.
Studies have been carried out where high dose thalidomide have been
administered to the patients with renal cell carcinoma (600 mg daily).Thalidomide
has been given to patient s who are refractory to the immunotherapy. The
partial response occurs in 9-10% patients with 30-50% patients show stable
disease for a period ranging from 6 -12 months.
We usually start patients on thalidomide if they cannot tolerate sunitinib .The side effects of sunitinib like oral ulcers sometimes cause patients to drop out from the therapy.But the toxic sideffects like neuropathy,asthenia,fatigue,constipation etc can happen.
Thanks for sharing the information about the Thalidomide in Metastatic Renal cell carcinoma.
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