U.S. Food and Drug Administration (FDA) has accepted for the potential use of tolvaptan for the treatment of Autosomal Dominant Polycystic Kidney Disease.
Mode of Action :
Tolvaptan, when administered with traditional diuretics, was noted to increase excretion of excess fluids and improve blood sodium levels in patients with heart failure without producing side effects such ashypotension (low blood pressure) or hypokalemia (decreased blood levels of potassium) and without having an adverse effect on kidney function.
In Autosomal Dominant Polycystic Kidney Disease:
Tolvaptan has been hypothesized to slow the progression of ADPKD by reducing the development and growth of kidney cysts, which are characteristic of the disease.
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